Johan P de Winter Selected Research

Fanconi Anemia (Fanconi's Anemia)

2/2015	DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity.
5/2013	Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia.
7/2012	A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.
1/2012	Diagnosis of Fanconi Anemia: Mutation Analysis by Multiplex Ligation-Dependent Probe Amplification and PCR-Based Sanger Sequencing.
2/2011	SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.
2/2010	Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1.
9/2009	Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.
7/2009	Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.
5/2007	Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype.
2/2007	Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.

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Johan P de Winter Research Topics

Disease

21	Fanconi Anemia (Fanconi's Anemia) 02/2015 - 10/2003
13	Hypersensitivity (Allergy) 12/2015 - 08/2004
10	Neoplasms (Cancer) 12/2015 - 10/2003
6	Chromosomal Instability (Chromosome Stability) 12/2015 - 06/2004
4	Breast Neoplasms (Breast Cancer) 09/2014 - 10/2003
4	Genomic Instability 05/2013 - 01/2005
4	Chromosome Breakage 01/2012 - 01/2007
3	Bone Marrow Failure Disorders 12/2015 - 08/2004
2	Inborn Genetic Diseases (Disease, Hereditary) 12/2015 - 08/2004
2	Complementation Group D1 Fanconi Anemia 02/2015 - 01/2006
2	Chromosome Aberrations (Chromosome Abnormalities) 01/2013 - 01/2012
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2005 - 08/2004
1	XFE Progeroid Syndrome 05/2013
1	Xeroderma Pigmentosum (Kaposi's Disease) 05/2013
1	Roberts Syndrome 02/2010
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2005
1	Infections 08/2004

Drug/Important Bio-Agent (IBA)

20	DNA (Deoxyribonucleic Acid)IBA 12/2015 - 10/2003
12	Proteins (Proteins, Gene)FDA Link 09/2014 - 10/2003
4	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2012 - 10/2003
4	A-Form DNA (A-DNA)IBA 01/2010 - 10/2003
4	Fanconi Anemia Complementation Group D2 ProteinIBA 01/2008 - 10/2003
3	UbiquitinIBA 07/2012 - 10/2003
3	Small Interfering RNA (siRNA)IBA 04/2007 - 01/2007
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 02/2015 - 09/2014
2	EndonucleasesIBA 05/2013 - 02/2011
2	Ligases (Synthetase)IBA 09/2005 - 10/2003
2	Cisplatin (Platino)FDA LinkGeneric 01/2005 - 08/2004
1	Paclitaxel (Taxol)FDA LinkGeneric 10/2015
1	PoisonsIBA 10/2015
1	apcinIBA 10/2015
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 09/2014
1	Carrier Proteins (Binding Protein)IBA 07/2012
1	diepoxybutaneIBA 01/2012
1	Histones (Histone)IBA 03/2010
1	Pharmaceutical PreparationsIBA 02/2010
1	AcetyltransferasesIBA 09/2009
1	CamptothecinIBA 07/2009
1	ChromatinIBA 02/2007
1	Archaeal DNAIBA 09/2005
1	PlatinumIBA 01/2005
1	Nuclear Proteins (Protein, Nuclear)IBA 11/2004
1	Fanconi Anemia Complementation Group G ProteinIBA 01/2004
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2003
1	Fanconi Anemia Complementation Group ProteinsIBA 10/2003

Therapy/Procedure

2	Therapeutics 01/2005 - 08/2004
1	Ligation 01/2012
1	Drug Therapy (Chemotherapy) 01/2005